Comparison 2.
Efficacy: Vertebroplasty versus usual care (open label)
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Pain (0 or 1 to 10 point scale) | 7 | Std. Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 1.1 1 to 2 weeks | 6 | 627 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.33 [‐2.26, ‐0.39] |
| 1.2 1 month | 3 | 384 | Std. Mean Difference (IV, Random, 95% CI) | ‐2.06 [‐3.35, ‐0.76] |
| 1.3 2 to 3 months | 6 | 627 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.18 [‐1.95, ‐0.40] |
| 1.4 6 months | 5 | 573 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.05 [‐1.82, ‐0.28] |
| 1.5 12 months | 6 | 612 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.02 [‐1.74, ‐0.30] |
| 1.6 24 months | 1 | 77 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.45 [‐0.90, 0.01] |
| 2 Disability (RMDQ [0 to 24] or ODI [0 to 100]) | 5 | Std. Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 2.1 1 to 2 weeks | 5 | 494 | Std. Mean Difference (IV, Random, 95% CI) | ‐2.06 [‐3.28, ‐0.83] |
| 2.2 1 month | 3 | 378 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.52 [‐3.00, ‐0.04] |
| 2.3 3 months | 4 | 460 | Std. Mean Difference (IV, Random, 95% CI) | ‐2.76 [‐4.65, ‐0.87] |
| 2.4 6 months | 4 | 461 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.84 [‐3.37, ‐0.30] |
| 2.5 12 months | 4 | 455 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.59 [‐2.79, ‐0.38] |
| 2.6 24 months | 1 | 77 | Std. Mean Difference (IV, Random, 95% CI) | ‐5.65 [‐6.67, ‐4.63] |
| 3 Quality of Life (QUALEFFO) | 4 | Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 3.1 1 to 2 weeks | 4 | 448 | Mean Difference (IV, Random, 95% CI) | ‐5.67 [‐11.65, 0.32] |
| 3.2 1 month | 2 | 289 | Mean Difference (IV, Random, 95% CI) | ‐10.18 [‐21.49, 1.13] |
| 3.3 2 to 3 months | 3 | 415 | Mean Difference (IV, Random, 95% CI) | ‐5.83 [‐15.41, 3.75] |
| 3.4 6 months | 3 | 415 | Mean Difference (IV, Random, 95% CI) | ‐5.14 [‐15.02, 4.74] |
| 3.5 12 months | 3 | 415 | Mean Difference (IV, Random, 95% CI) | ‐3.40 [‐9.90, 3.11] |
| 4 Quality of life (EQ5D) | 2 | Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 4.1 1 to 2 weeks | 1 | 183 | Mean Difference (IV, Random, 95% CI) | 0.08 [0.00, 0.15] |
| 4.2 1 month | 1 | 183 | Mean Difference (IV, Random, 95% CI) | 0.09 [0.01, 0.16] |
| 4.3 3 months | 2 | 215 | Mean Difference (IV, Random, 95% CI) | 0.10 [0.00, 0.20] |
| 4.4 6 months | 1 | 183 | Mean Difference (IV, Random, 95% CI) | 0.07 [‐0.02, 0.15] |
| 4.5 12 months | 2 | 215 | Mean Difference (IV, Random, 95% CI) | 0.07 [‐0.00, 0.14] |
| 5 Treatment success | 1 | Risk Ratio (M‐H, Random, 95% CI) | Totals not selected | |
| 5.1 12 months | 1 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |