Table 5. Longitudinal laboratory value data for subset of patients with complete longitudinal data, stratified by the presence of TIC at hour 0.
Data are presented as median (interquartile range). P-values obtained by Wilcoxon rank-sum test.
| Lab Value | Non-TIC (n=38) | TIC (n=12) | P |
|---|---|---|---|
| Platelet count, x109/L (REF 150–450): | |||
| Hour 0 | 243 (179–284) | 217 (151–265) | 0.156 |
| Hour 8 | 208 (174–256) | 181 (115–248) | 0.251 |
| Hour 24 | 190 (155–240) | 142 (115–185) | 0.044 |
| Hour 48 | 176 (139–231) | 132 (107–145) | 0.005 |
| Hour 72 | 186 (147–237) | 122 (109–151) | 0.001 |
| PT, sec (REF 11–15): | |||
| Hour 0 | 14.7 (13.7–15.3) | 20.2 (19.3–21.2) | <0.001 |
| Hour 8 | 14.4 (13.8–15.6) | 16.7 (16.0–18.1) | <0.001 |
| Hour 24 | 15.2 (14.0–17.2) | 17.8 (17.2–18.6) | <0.001 |
| Hour 48 | 15.6 (14.2–16.9) | 17.2 (15.2–17.9) | 0.071 |
| Hour 72 | 14.8 (13.8–16.6) | 16.2 (15.1–17.6) | 0.030 |
| aPTT, sec (REF 25–40): | |||
| Hour 0 | 32.3 (29.0–35.7) | 39.0 (32.6–46.1) | 0.007 |
| Hour 8 | 33.9 (30.4–36.8) | 34.6 (32.3–39.4) | 0.570 |
| Hour 24 | 39.9 (34.8–44.7) | 41.1 (38.1–47.2) | 0.394 |
| Hour 48 | 41.1 (35.9–47.0) | 42.1 (36.6–52.3) | 0.733 |
| Hour 72 | 39.7 (36.4–44.6) | 45.7 (39.9–55.8) | 0.058 |
| Fibrinogen concentration, mg/dL (REF 250–400): | |||
| Hour 0 | 223 (194–326) | 132 (113–172) | <0.001 |
| Hour 8 | 245 (209–307) | 202 (153–269) | 0.073 |
| Hour 24 | 418 (352–489) | 389 (305–474) | 0.264 |
| Hour 48 | 629 (516–717) | 574 (465–714) | 0.577 |
| Hour 72 | 694 (612–819) | 746 (642–864) | 0.411 |
| PFA-100 collagen/epinephrine closure time, sec (REF <180): | |||
| Hour 0 | 98 (85–152) | 130 (108–214) | 0.090 |
| Hour 8 | 107 (84–143) | 108 (78–127) | 0.768 |
| Hour 24 | 102 (86–171) | 120 (95–157) | 0.715 |
| Hour 48 | 111 (86–140) | 144 (123–296) | 0.029 |
| Hour 72 | 103 (92–142) | 144 (103–217) | 0.222 |
| PFA-100 collagen/ADP closure time, sec (REF <120): | |||
| Hour 0 | 64 (53–82) | 70 (52–79) | 0.955 |
| Hour 8 | 66 (56–78) | 87 (59–211) | 0.039 |
| Hour 24 | 83 (67–96) | 100 (71–112) | 0.122 |
| Hour 48 | 99 (77–136) | 157 (114–236) | 0.005 |
| Hour 72 | 100 (81–147) | 279 (99–300) | 0.018 |
| Platelet ADP aggregation, ohms (REF 6–24): | |||
| Hour 0 | 10.8 (7.5–13.0) | 7.3 (4.5–8.0) | 0.002 |
| Hour 8 | 9.5 (7.0–13.0) | 9.8 (5.5–12.3) | 0.609 |
| Hour 24 | 10.5 (7–15) | 10.3 (6–12) | 0.593 |
| Hour 48 | 10.5 (8.5–13) | 11 (9.3–13.3) | 0.501 |
| Hour 72 | 11.3 (9–15) | 10.5 (7.5–16.3) | 0.524 |
| Platelet collagen aggregation, ohms (REF 14–28): | |||
| Hour 0 | 14.5 (11.5–17.5) | 11.0 (6.8–12.5) | 0.001 |
| Hour 8 | 12.5 (10.0–16.0) | 11.8 (8.0–14.0) | 0.363 |
| Hour 24 | 13.8 (11.0–15.5) | 15.0 (11.3–16.5) | 0.481 |
| Hour 48 | 13.5 (11.5–15.5) | 13.8 (12.3–16.3) | 0.759 |
| Hour 72 | 14.3 (11.0–18.0) | 13.0 (11.8–17.3) | 0.955 |
| HAS platelet contractile force, kdynes (REF 4.5–9.5): | |||
| Hour 0 | 8.4 (6.8–9.6) | 5.8 (3.8–8.1) | 0.002 |
| Hour 8 | 6.7 (5.2–9.3) | 6.4 (5.6–7.7) | 0.388 |
| Hour 24 | 6.9 (5.0–8.6) | 8.2 (7.2–11.0) | 0.122 |
| Hour 48 | 9.1 (5.9–13.1) | 9.5 (6.5–11.8) | 0.867 |
| Hour 72 | 10.2 (7.6–14.4) | 8.0 (7.7–13.8) | 0.668 |
| HAS clot elastic modulus, kdynes/cm2 (REF 14–35): | |||
| Hour 0 | 29.2 (22.9–37.0) | 23.6 (17.9–30.0) | 0.051 |
| Hour 8 | 23.6 (18.6–30.9) | 20.7 (16.4–26.3) | 0.388 |
| Hour 24 | 24.7 (17.6–31.9) | 26.9 (21.2–40.5) | 0.273 |
| Hour 48 | 41.8 (17.4–47.3) | 26.3 (17.1–42.0) | 0.403 |
| Hour 72 | 37.8 (21.7–52.0) | 21.5 (16.0–56.4) | 0.384 |
| TEG MA, mm (REF 50–70): | |||
| Hour 0 | 63.0 (58.8–65.1) | 54.6 (50.9–59.1) | <0.001 |
| Hour 8 | 61.7 (58.3–66.0) | 62.6 (58.2–64.1) | 0.586 |
| Hour 24 | 64.0 (61.9–67.1) | 64.9 (61.4–66.2) | 0.901 |
| Hour 48 | 67.3 (65.1–70.4) | 65.2 (64.2–69.1) | 0.303 |
| Hour 72 | 68.9 (66.6–72.0) | 69.4 (64.8–71.6) | 0.650 |
| TEG LY30, % (REF <7.5): | |||
| Hour 0 | 0.2 (0–1.4) | 2.3 (0.1–5.8) | 0.074 |
| Hour 8 | 0.1 (0–0.6) | 0 (0–0.3) | 0.446 |
| Hour 24 | 0.7 (0–1.6) | 0.7 (0.1–1.6) | 0.836 |
| Hour 48 | 1.1 (0.2–2.6) | 1.3 (0.2–2.1) | 0.980 |
| Hour 72 | 0.6 (0–2.1) | 0.7 (0.1–1.3) | 0.605 |
| TEG-PM ADP inhibition, %: | |||
| Hour 0 | 81.4 (61.4–94.7) | 94.6 (64.4–99.8) | 0.291 |
| Hour 8 | 57.4 (38.0–96.4) | 67.5 (28.4–96.7) | 0.706 |
| Hour 24 | 37.9 (30.0–61.5) | 27.9 (19.4–84.4) | 0.484 |
| Hour 48 | 35.7 (19.4–63.8) | 26.3 (10.0–54.3) | 0.443 |
| Hour 72 | 42.2 (27.2–61.0) | 44.4 (7.1–61.7) | 0.886 |
| TEG-PM AA inhibition, %: | |||
| Hour 0 | 40.7 (21.8–62.9) | 37.2 (24.7–54.5) | 0.706 |
| Hour 8 | 36.8 (17.6–86.0) | 40.2 (1.2–61.5) | 0.641 |
| Hour 24 | 23.3 (6.3–62.8) | 16.8 (9.4–27.3) | 0.511 |
| Hour 48 | 24.9 (1.6–59.1) | 6.0 (0–24.4) | 0.206 |
| Hour 72 | 21.4 (0–55.7) | 7.5 (0–28.1) | 0.569 |
| Percent PAC-1-positive: | |||
| Hour 0 | 3.7 (2.1–12.5) | 3.1 (0.5–13.1) | 0.417 |
| Hour 8 | 10.5 (0.3–35.7) | 11.0 (4.7–18.9) | 0.980 |
| Hour 24 | 12.4 (2.2–25.9) | 14.7 (4.7–19.0) | 0.979 |
| Hour 48 | 18.6 (8.5–30.6) | 12.7 (5.0–17.8) | 0.341 |
| Hour 72 | 14.4 (3.4–28.1) | 19.3 (1.8–30.9) | 0.716 |
| Percent CD62P-positive: | |||
| Hour 0 | 3.2 (1.3–7.9) | 2.4 (0.9–2.6) | 0.180 |
| Hour 8 | 2.8 (0.8–5.1) | 2.4 (1.5–3.8) | 0.910 |
| Hour 24 | 1.6 (0.4–3.8) | 1.1 (0.9–2.0) | 0.577 |
| Hour 48 | 1.6 (0.6–4.8) | 0.8 (0.6–2.3) | 0.458 |
| Hour 72 | 2.0 (0.8–8.5) | 2.8 (1.3–3.4) | 0.874 |
| Percent that became CD62P-positive after ADP stimulation: | |||
| Hour 0 | 69.6 (59.6–75.8) | 65.8 (49.5–75.1) | 0.585 |
| Hour 8 | 64.9 (57.6–72.6) | 64.1 (55.9–67.9) | 0.471 |
| Hour 24 | 69.6 (55.3–75.1) | 60.6 (53.2–67.5) | 0.178 |
| Hour 48 | 68.2 (58.2–73.1) | 58.3 (54.0–69.7) | 0.270 |
| Hour 72 | 67.6 (55.3–74.0) | 66.6 (60.3–73.9) | 0.803 |