. Author manuscript; available in PMC: 2019 Aug 6.

Published in final edited form as: JAMA Otolaryngol Head Neck Surg. 2019 Feb 1;145(2):166–177. doi: 10.1001/jamaoto.2018.2716

Table 3.

Treatment Package Time (TPT)

Source	Country	Definition of Delayed TPT	Derivation of Definition of Delay	Data Source	Sample Size, No.	Years of Diagnosis or Treatment	Freq of Delay, %	HNSubsite, %	AJCC Stage Grouping, %	Treatment Modality, %	Association of Delay to Survival, aHR(95%CI)	Quality Score
Tam et al,²⁰ 2018	United States	1: >13 wk 2: >97 d	1: Prespecified (prior data) 2: RPA	National sample of CoC-accredited hospitals	16 733	2005–2012	1: >13 wk, 66 2: >97 d: NR	OC: 41 OP: 42 HP: 3 Lx: 14	Pathologic I: 2 II: 3 III: 13 IV: 62 Unk: 20	S + CRT: 100	OS (prespecified) ≤13 wk, 1 [Ref] >13 wk, 1.07 (1.01–1.13)^a Median OS (RPA) ≤97 d, 10.0 y >97 d, 8.2 y	13
Guttmann et al,¹⁸ 2018	United States	≥11 wk	Not specified	National sample of CoC-accredited hospitals	15 234	2004–2012	NR	OC: 29 OP: 55 HP: 2 Lx: 14	Pathologic III: 24 IV: 76	S + RT: 37 S + CRT: 61 Unk: 1	OS <11 wk, 1 [Ref] 11–12 wk, 1.19 (1.03–1.37) 13–15 wk, 1.36 (1.18–1.56) ≥16 wk, 1.51 (1.31–1.74)	12
Chen et al,¹⁹ 2018	United States	>11 wk	Not specified	Single academic medical center	132	2008–2016	>11 wk: 73	OC: 100	Pathologic I: 7 II: 18 III: 12 IV: 63	S + RT: 51 S + CRT: 49	OS ≤11 wk, 1 [Ref] >11 wk, 6.68 (1.42–31.4) RFS ≤11 wk, 1 [Ref] >11 wk, 2.94 (1.20–7.18)	12
Fujiwara et al,³⁰ 2017	United States	≥161 d	Cohort quartiles	National sample of CoC-accredited hospitals	1462	1998–2011	≥161 d: 25	OC: 100	Unspecified I: 9 II: 16 III: 18 IV: 57	S + RT: 68 S + CRT: 32	OS ≤136 d, 1 [Ref] 136–161 d: NR ≥161 d, 0.98 (0.82–1.17)	12
Tribius et al,⁴⁰ 2016	Germany	1: ≥100 d 2: ≥87 d	1: Not specified 2: Decision tree	Single institution	272	2004–2014	1: ≥100 d, 18 2: ≥87 d, 45	OC: 27 OP: 39 HP or Lx: 16 Other: 18	Unspecified III: 35 IV: 65	S + RT: 57 S + CRT: 43	OS <100 d, 1 [Ref] ≥100 d, 4.1 (2.04–8.27) <87 d, 1 [Ref] ≥7 d, 3.3 (1.52–7.03) DFS <100 d, 1 [Ref] ≥100 d, 1.8 (0.76–4.18) <87 d, 1 [Ref] ≥87 d, 2.2 (1.04–4.59)	13

Abbreviations: aHR, adjusted hazard ratio; AJCC, American Joint Committee on Cancer; CoC, Commission on Cancer; CRT, chemoradiotherapy; DFS, disease-free survival; Freq, Frequency; HN, head and neck; HP, hypopharynx; Lx, larynx; NR, not reported; OC, oral cavity; OP, oropharynx; OS, overall survival; Ref, Reference; RFS, recurrence-free survival; RPA, recursive partitioning analysis; RT, radiotherapy; S, surgery; Unk, unknown.

Discrepancy between results reported in abstract (aHR, 1.10; 95%CI, 1.04–1.17) and results and tables (aHR, 1.07; 95%CI, 1.01–1.13).