Table 1.

Patient and biopsy characteristics

Age	Sex	History	Days on ECMO prior to biopsy	Systemic anticoagulation prior to biopsy	Procedure	Pathology	Impact on Management	Transfusions during the 5 days prior to biopsy (units)	Transfusions during the 3 days following biopsy (units)	New PTX following procedure	Survival to hospital discharge
26	F	DAH without known autoimmune disease	2	No	VATS	DAD without capillaritis	Cytotoxic therapy withheld	2	3	No	No
66	M	ARDS following HSCT	23	Yes	Tbbx with cup forceps	Organizing pneumonia	None (Continued on steroids)	3	1	No	No
66	F	ARDS, concern for rapidly progressive ILD	1	No	Cryobiopsy	DAD	None	2	4	No	No
78	M	ARDS with CMV viremia	10	No	Tbbx with cup forceps	DAD, no CMV seen	None	3	0	No	No
32*	F	Lung transplant recipient with ARDS and CMV viremia	20	No	Tbbx with cup forceps	DAD, no acute rejection, + CMV inclusions	Immunosuppressive medication reduced, continued on antiviral therapy	3	1	No	No
32*	F	Lung transplant recipient with ARDS and CMV viremia	50	Yes	Tbbx with cup forceps	Scant lung parenchyma with chronic inflammation. No CMV	None	4	6	No	No
43	F	ARDS & Influenza A (H1N1)	10	Yes	Wedge resection during emergent thoracotomy for hemothorax	DAD, negative infectious stains	None	11	3	No	Yes
56	F	ARDS and Influenza A	3	Yes	Cryobiopsy	DAD and organizing pneumonia	None (Continued on steroids)	3	0	No	Yes
19	F	ARDS & disseminated adenovirus	11	Yes	Mini-thoracotomy	DAD and organizing pneumonia, necrotizing candida lusitaniae pneumonia	None (Continued on micafungin)	5	8	No	No
62	M	ARDS	13	No	Wedge resection during exploratory thoracotomy for intrathoracic hematoma evacuation	Chronic inflammation with areas of organization	None	13	8	No	No

Abbreviations: ARDS, acute respiratory distress syndrome; CMV, cytomegalovirus; DAD, diffuse alveolar damage; DAH, diffuse alveolar hemorrhage; ECMO, extracorporeal membrane oxygenation; HSCT, hematopoietic stem cell transplant; ILD, interstitial lung disease; F, female; M, male; Pt, patient; PTX, pneumothorax; Tbbx, transbronchial biopsy; VATS, video-assisted thoracoscopic surgery

^*Patient underwent two separate lung biopsy procedures