Figure 1. IM156 reduces antigen-specific effector memory T cells in LCMV-infected mice.

LCMV-infected mice were treated with DMSO (), IM156 (), or rapamycin () from days −1 to 29 post-infection. (A) Representative plot showing the frequency of GP33 tetramer-positive cells among CD8⁺ or CD4⁺ T cells in PBMCs at the indicated days post-infection. (B) Kinetics of GP33⁺ T cells among CD8⁺ T cells as in A. (C) Co-expression of either KLRG1 (left) or CD62L (right) and CD127 on tetramer-positive CD8⁺ T cells obtained from PBMCs at the indicated days post-infection. (D) Frequency of MPECs (CD127^hiCD62L^lo) and SLECs (CD127^loCD62L^hi) as in C. (E) Frequency of T_CM (CD127⁺CD62L⁺), T_EM (CD127⁺CD62L⁻), and T_EFF (CD127⁻CD62L⁻) as in C. Data are representative of 3 independent experiments with n=4 mice per group. Results are the mean ± SEM and statistical significance was determined by 2-tailed unpaired Student's t-test.

^*p<0.05; ^**p<0.01; ^***p<0.001.