Table 2. Methodological characteristics and outcomes measured by the included studies.
| Authors (year) | Reference | Intervention | Design | FU (yr) | Patients | Test | Control | Other treatments | Outcomes |
|---|---|---|---|---|---|---|---|---|---|
| Axelsson & Lindhe (1981) | [38] | Surgery | PCS | 6 | 25 | MWF | PI, GI, PD, CAL | ||
| Crespi et al. (2011) | [35] | Surgery | RCT split | 15 | 25 | FOS+CO2L | MWF | PI, GI, PD, CAL | |
| Gaspirc & Skaleric (2007) | [57] | Surgery | RCT split | 5 | 25 | MWF+Er:YAG | MWF | GI, PI, BOP, PD, REC, CAL | |
| Isidor & Karring (1986) | [39] | Surgical/non-surgical | CCT | 5 | 16 | MWF | SRP | RBF | PI, GI, PD, CAL |
| Kaldahl et al. (1996) | [43] | Surgical/non-surgical | RCT | 7 | 51 | FOS | MWF | SRP, CSC | PI, PD, CAL, BOP, REC, SUP, TL |
| Kaldahl et al. (1996) | [31] | Surgical/non-surgical | RCT | 7 | 51 | FOS | MWF | SRP, CSC | PD, CAL |
| Lindhe et al. (1984) | [42] | Surgical/non-surgical | RCT split | 5 | 11 | MWF | SRP | CAL, PD | |
| Pihlstrom et al. (1983) | [32] | Surgical/non-surgical | RCT split | 6.5 | 10 | MWF | SRP | CAL, PD | |
| Pihlstrom et al. (1984) | [33] | Surgical/non-surgical | RCT split | 6.5 | 10 | MWF | SRP | CAL, PD, TL | |
| Preus et al. (2017) | [36] | Non-surgical | RCT | 5 | 161 | SRP+MET | SRP+PL | FMDIS+PL, FMDIS+MET | PI, BOP, PD, CAL |
| Ramberg et al. (2001) | [37] | Non-surgical | CCT | 5 | 115 | SRP+TTR | SRP | PI, BOP, CAL, PD, RX | |
| Ramfjord et al. (1975) | [56] | Surgical/non-surgical | RCT split | 5 | 79 | MWF | CUR | PE | CAL, PD |
| Knowles et al. (1979) | [30] | Surgical/non-surgical | RCT split | 8 | 43 | MWF | CUR | PE | CAL, PD |
| Ramfjord et al. (1987) | [41] | Surgical/non-surgical | RCT split | 5 | 72 | MWF | SRP | PE, CUR | CAL, PD, TL |
| Renvert et al. (1996) | [55] | Surgical/non-surgical | CS | 5 | 12 | MWF | SRP | CAL, PD, Micro | |
| Rosling et al. (2001) | [34] | Non-surgical | PCS | 12 | 334 | SRP | CAL, PD, PI, TL, RX | ||
| Serino et al. (2001) | [40] | Surgical/non-surgical | RCT | 13 | 64 | MWF | SRP | CAL, BOP, PD, RX |
BOP: bleeding on probing, CAL: clinical attachment level, CCT: Controlled clinical trial, CO2L, CO2 laser, CS: case series, CSC: coronal scaling, CUR: curettage, FU: follow-up, FOS: flap osseous surgery, FMDIS: full mouth disinfection, GI: gingival index, MET: metronidazole, Micro: microbiology, MWF: modified Widman flap, PCS: prospective cohort study, PD: probing depth, PE: pocket elimination, PL: placebo, PI: plaque index, RBF: reverse bevel flap, RCT: randomized controlled trial, REC: recession, RX: radiograph, SRP: scaling and root planing, SUP: suppuration, TL: tooth loss, TTR: tetracycline.