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Muscle weight analysis. (A and B) Muscle weights at 3 months (n = 9–10). Raw values are normalized to tibia length. Relative weights obtained by normalization to wild-type averages. (C) Muscle weight deficits observed throughout homozygous lifespan (n = 9, 6, 4). Two-way ANOVA reveals age has a significant effect on the diaphragm (P < 0.0001), with soleus trending (P = 0.06) and EDL being not significant (P = 0.3).
