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. 2019 May 1;9:6751. doi: 10.1038/s41598-019-43230-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Differentially expressed probe sets (N = 6,540) were clustered hierarchically using Pearson correlation as a distance metric. (B) The correlation of average fold change between romidepsin and belinostat samples. The magnitude of the correlation coefficients is represented by the intensity of blue, dark being highly correlated, and by the shape of ellipses, with narrow being highly correlated. These panels show that rombidepsin and belinostat induced similar, directional changes in gene expression but the magnitude of the expression differential (relative to controls) was greater for romidepsin-treated embryos.