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. 2019 May 1;9:6759. doi: 10.1038/s41598-019-42894-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of aging on the potency of TXA₂-R and AT₁-R antagonists. Comparison of concentration-response curves for U46619 in the presence of SQ29548 (A) and for Ang II in the presence of losartan (B) show that aging significantly increases the blocking effects of the selective antagonists of their respective GPCR agonists (C,D) (*P < 0.05; n = 8). These data imply that aging may lead to a decrease in the GPCR population.