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. 2019 May 1;10(5):355. doi: 10.1038/s41419-019-1589-y

Fig. 8. Administration of 3-DZNeP restored loss of E-cardherin and protects against cisplatin-induced acute kidney injury.

Fig. 8

Representative sections of periodic acid-Schiff (PAS) staining of kidney tissue (magnification ×200) (a). Blood was collected at 72 h after cisplatin injection in C57BL/6J mice. Serum creatinine (Scr) and blood urea nitrogen (BUN) were detected as levels of kidney function (c, d). Kidney tissue lysates were subjected to immunoblot analysis with antibodies against E-cadherin, neutrophil gelatinase-associated lipocalin (NGAL), caspase-3 (cas3), EZH2, H3K27me3, H3, and β-actin (b). Data represent the mean ± SEM of at least three mice. The levels of E-cadherin (e), NGAL (f), cleaved-cas3 (g), EZH2 (h), or H3K27me3 (i), were quantified by densitometry and normalized with β-actin or H3 as indicated. Data represent the mean ± SEM of at least three mice. Bars with different letters (a–c) for each molecule are significantly different from one another (P < 0.05). SL saline, CP cisplatin