Table 2.
Pairwise correlation analysis of subunit gene expression across levels, from single cell to global brain expression
| Positive correlations | Negative correlations | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Gene | Subunits | From datasets | Cell class (C,D) | Gene | Gene | Subunits | Cell class (C,D) | |
| GABRA1 | GABRB2 | α1−β2 | A,B,C,D | Exc, 1 Inh | GABRA1 | GABRA2 | α1, α2 | B,C,D | 9 Exc, 2 Inh |
| GABRA1 | GABRD | α1−δ | B,D | 1 Exc | GABRA1 | GABRA3 | α1, α3 | B,D | 1 Exc |
| GABRA2 | GABRA4 | α2−α4 | A,C | Exc, Inh | GABRA1 | GABRA4 | α1, α4 | C,D | 4 Exc, 2 Inh |
| GABRA2 | GABRB1 | α2−β1 | A,B | GABRA1 | GABRA5 | α1, α5 | D | 2 Exc, 1 Inh | |
| GABRA2 | GABRB3 | α2−β3 | A,D | 1 Inh | GABRA1 | GABRB1 | α1, β1 | A,B,C,D | 1 Exc, 1 Inh |
| GABRA3 | GABRB1 | α3−β1 | A,B,C,D | 1 Exc | GABRA1 | GABRB3 | α1, β3 | A,C | |
| GABRA4 | GABRB2 | α4−β2 | B,D | 1 Exc | GABRA1 | GABRG1 | α1, γ1 | A,B,C | |
| GABRA4 | GABRD | α4−δ | B,C | Exc | GABRA2 | GABRA4 | α2, α4 | B,D | 1 Exc |
| GABRB1 | GABRB3 | β1−β3 | A,C | Inh | GABRA2 | GABRB2 | α2, β2 | B,C,D | 1 Exc, 1 Inh |
| GABRB1 | GABRG1 | β1−γ1 | A,B | GABRA2 | GABRG2 | α2, γ2 | B,D | 1 Inh | |
| GABRA3 | GABRD | α3, δ | A,B | ||||||
| GABRA5 | GABRB2 | α5, β2 | B,C | Inh | |||||
| GABRA5 | GABRG2 | α5, γ2 | B,C | ||||||
| GABRA5 | GABRG2 | α5, δ | B,C | ||||||
| GABRB1 | GABRB2 | β1, β2 | A,B,C,D | 2 Exc, 4 Inh | |||||
| GABRB1 | GABRB3 | β1, β3 | D | 2 Exc | |||||
| GABRB1 | GABRAD | β1, δ | A,B,C,D | 1 Exc | |||||
| GABRB2 | GABRB3 | β2, β3 | D | 11 Exc, 3 Inh | |||||
| GABRB2 | GABRG1 | β2, γ1 | A,B,C,D | 1 Exc | |||||
| GABRB3 | GABRG2 | β3, γ2 | C,D | 1 Inh | |||||
| GABRG1 | GABRG2 | γ1, γ2 | B,D | 4 Exc | |||||
| GABRG1 | GABRD | γ1, δ | A,B | ||||||
| GABRG2 | GABRD | γ2, δ | A,D | 4 Exc, 3 Inh | |||||
Dataset A: Allen Atlas Microarray study, Dataset B: Aging, Dementia and Traumatic Brain Injury study, Datasets C and D: Allen Institute Cell-type study across excitatory and inhibitory cells and within each cell-type cluster, respectively. Cell class was determined from datasets C and D. Subunits in bold indicate pairs with positive and negative correlations across different analyses