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. 2019 Apr 25;9:280. doi: 10.3389/fonc.2019.00280

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Copyright © 2019 Winfield, Miah, Strauss, Thway, Collins, deSouza, Leach, Morgan, Giles, Moskovic, Hayes, Smith, Zaidi, Henderson and Messiou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Median ADC estimates pre- and post-radiotherapy. Ladder plot showing median ADC estimates for 13 patients pre- and post-radiotherapy (solid lines). In patients undergoing two baseline examinations, the mean of two estimates was used. Dashed line shows mean values for the cohort. Asterisks show four patients exhibiting post-treatment increases in median ADC outside baseline 95% LoA (One patient who underwent radiotherapy was excluded from ADC analysis as the tumor [well-differentiated liposarcoma] was composed of more than 80% fat and was therefore not evaluable using fat-suppressed diffusion-weighted imaging).