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. 2019 Apr 25;9:280. doi: 10.3389/fonc.2019.00280

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Copyright © 2019 Winfield, Miah, Strauss, Thway, Collins, deSouza, Leach, Morgan, Giles, Moskovic, Hayes, Smith, Zaidi, Henderson and Messiou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological assessment of cellularity. Natural logarithm of nuclear-to-stromal ratio (estimated from histopathological analysis) vs. (A) apparent diffusion coefficient (ADC, estimated from DW-MRI) and (B) diffusion coefficient (D, from IVIM model of DW-MRI). Each point represents one ROI. Solid black line shows line of best fit. Points are labeled by histopathological assessment of stroma type (myxoid, fibromyxoid, or fibrous), with fibrous stroma types labeled by stroma grade (lower grades 1–2, and higher grades 3–5). ROIs that consisted of more than 80% fat were excluded from analysis of ADC and D.