. 2019 Apr 25;9:280. doi: 10.3389/fonc.2019.00280

Table 2.

ADC estimates reported in previous studies of soft-tissue sarcoma and osteosarcoma.

Tumors	Patients	ADC estimates
Soft-tissue sarcomas (mixed sub-types) in trunk and limbs	13	Mean ADCs between 0.9 × 10⁻³ mm² s⁻¹ and 2.3 × 10⁻³ mm² s⁻¹ in pre-treatment measurements (16)
Soft-tissue sarcomas (mixed sub-types) in trunk, limbs, and head	23	Mean ADCs between 0.79 × 10⁻³ mm² s⁻¹ and 2.01 × 10⁻³ mm² s⁻¹ in pre-treatment measurements (17)
Osteosarcoma	31	Mean ADCs between 0.92 × 10⁻³ mm² s⁻¹ and 1.67 × 10⁻³ mm² s⁻¹ at baseline and between 1.08 × 10⁻³ mm² s⁻¹ and 2.24 × 10⁻³ mm² s⁻¹ after chemotherapy (18)
Osteosarcoma	35	Mean ADCs (1.24 ± 0.17) × 10⁻³ mm² s⁻¹ at baseline and (1.93 ± 0.39) × 10⁻³ mm² s⁻¹ after chemotherapy (19)
Osteosarcoma (pediatric)	8	Mean ADCs (2.1 ± 0.4) × 10⁻³ mm² s⁻¹ at baseline and (2.5 ± 0.4) × 10⁻³ mm² s⁻¹ after chemotherapy (20)
Osteosarcoma and Ewing sarcoma	18	Mean ADCs 1.35 × 10⁻³ mm² s⁻¹ at baseline and 1.64 × 10⁻³ mm² s⁻¹ after chemotherapy in tumors with < 90% necrosis post-treatment; mean ADCs 1.09 × 10⁻³ mm² s⁻¹ at baseline and 2.01 × 10⁻³ mm² s⁻¹ after chemotherapy in tumors with more than 90% necrosis post treatment (21)