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. 2019 May 7;73(17):2150–2162. doi: 10.1016/j.jacc.2019.01.070

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Central Illustration — Lp(a) and OxPL Drive Disease Progression by Aggravating Calcification in Aortic Stenosis Patients

Aortic stenosis patients with elevated levels of Lp(a) and OxPL-apoB demonstrate increased calcification activity in the valve as measured by ¹⁸F-NaF PET, compared with patients with low levels of Lp(a) and OxPL-apoB. During follow-up, this resulted in faster progression of CT calcium score and faster hemodynamic progression as measured by echocardiography. Ultimately, these patients have an increased risk of aortic valve replacement and death. Lp(a) = lipoprotein(a); OxPL-apoB = oxidized phospholipids on apolipoprotein B-100.