Table 2.

Multiple Linear Regression Analysis

	18F-NaF PET Activity: TBRMDSmean			Progression in AV Calcium Score: ΔCa-Score (100 AU/yr)			Change in Peak Aortic Jet Velocity: Vmax, m/s/yr
	Unst. β (95% CI)	Std. β	p Value	Unst. β (95% CI)	Std. β	p Value	Unst. β (95% CI)	Std. β	p Value
Age, per 10 yrs	0.100 (−0.019 to 0.218)	0.192	0.098	−0.253 (−1.016 to 0.511)	−0.082	0.507	0.006 (−0.034 to 0.046)	0.029	0.771
Male	0.160 (−0.087 to 0.408)	0.189	0.200	1.030 (−0.488 to 2.547)	0.225	0.178	−0.033 (−0.123 to 0.058)	−0.073	0.477
Body mass index, kg/m2	0.018 (−0.005 to 0.041)	0.179	0.126	−0.126 (−0.324 to 0.072)	−0.186	0.204	0.004 (−0.005 to 0.014)	0.092	0.349
Cardiovascular disease	−0.002 (−0.216 to 0.212)	−0.002	0.986	0.102 (−1.107 to 1.310)	0.023	0.866	0.029 (−0.057 to 0.114)	0.068	0.508
Smoking	−0.069 (−0.231 to 0.093)	−0.085	0.395	−0.559 (−1.505 to 0.386)	−0.128	0.238	−0.017 (−0.097 to 0.062)	−0.041	0.666
Diabetes mellitus	−0.164 (−0.422 to 0.094)	−0.151	0.208	0.056 (−1.662 to 1.774)	0.010	0.948	−0.086 (−0.222 to 0.050)	−0.124	0.214
Hypertension	0.048 (−0.145 to 0.241)	0.054	0.621	−0.406 (−1.561 to 0.749)	−0.084	0.481	−0.027 (−0.106 to 0.053)	−0.065	0.506
Creatinine, per 10 mg/dl	0.004 (−0.026 to 0.034)	0.026	0.811	−0.201 (−0.410 to 0.008)	−0.256	0.059	−0.001 (−0.018 to 0.015)	−0.016	0.874
Lipoprotein(a) top tertile	0.262 (0.095 to 0.410)	0.307	0.002	1.453 (0.515 to 2.391)	0.328	0.003	0.086 (0.007 to 0.166)	0.197	0.034
Baseline AV Ca-score, per 100 AU	0.012 (0.007 to 0.018)	0.529	<0.001	0.109 (0.071 to 0.147)	0.670	<0.001	—	—	—
Baseline Vmax, m/s	—	—	—	—	—	—	0.040 (−0.012 to 0.093)	0.144	0.130

AV Ca-score = aortic valve calcium score; CI = confidence interval; Std. β = standardized beta coefficient; TBR_MDSmean = tissue-to-background ratio of the most diseased segment; Unst. β = unstandardized beta coefficient; V_max = peak aortic jet velocity.