Table 2.
Impact of Intensive Versus Standard Anthelminthic Treatment on Primary Outcomes
| Outcome | n/N (%)/Geometric Mean | Unadjusted | Adjusted for Outcome at Baseline by Age and Sexa | |||
|---|---|---|---|---|---|---|
| Standard | Intensive | RR/GMR (95% CI) |
P Value | RR/GMR (95% CI) |
P Value | |
| Wheeze (age ≥5 years)b | 44/1384 (3.2%) | 43/1392 (3.1%) | 1.06 (0.61–1.87) | .82 | 1.11 (0.64–1.93) | .69 |
| Wheeze (age <5 years) | 6/284 (2.1%) | 3/264 (1.1%) | ||||
| Atopy (SPT) | ||||||
| SPT positivity to any allergen | 273/1514 (18.0%) | 303/1523 (19.9%) | 1.09 (0.83–1.44) | .51 | 1.10 (0.85–1.42) | .46 |
| SPT positivity to Dermatophagoides | 162/1514 (10.7%) | 164/1523 (10.8%) | 0.98 (0.72–1.35) | .92 | 1.00 (0.74–1.36) | .99 |
| SPT positivity to Blomia tropicalis | 102/1514 (6.7%) | 127/1522 (8.3%) | 1.26 (0.83–1.90) | .26 | 1.27 (0.85–1.91) | .22 |
| SPT positivity to German cockroach | 156/1513 (10.3%) | 194/1522 (12.8%) | 1.24 (0.87–1.77) | .20 | 1.22 (0.87–1.71) | .21 |
| Atopy (IgE detected by ImmunoCAP) | ||||||
| Dermatophagoides or cockroach positivity (>0.35 kUa/L) | 214/390 (54.9%) | 210/390 (53.9%) | 0.97 (0.83–1.13) | .67 | 0.96 (0.82–1.12) | .60 |
| Dermatophagoides positivity (asIgE > 0.35 kUa/L) | 134/390 (34.4%) | 130/390 (33.3%) | 0.95 (0.76–1.20) | .67 | 0.96 (0.77–1.19) | .68 |
| German cockroach positivity (asIgE > 0.35 kUa/L) | 201/390 (51.5%) | 192/390 (49.2%) | 0.94 (0.80–1.11) | .47 | 0.94 (0.79–1.11) | .42 |
| Concentration of asIgE to Dermatophagoides (kUa/L)c | GM: 0.158 | GM: 0.129 | 0.78 (0.51–1.17) | .22 | 0.77 (0.52–1.13) | .17 |
| Concentration of asIgE to German cockroach (kUa/L)c | GM: 0.342 | GM: 0.289 | 0.82 (0.55–1.22) | .31 | 0.81 (0.55–1.20) | .28 |
| Atopy (IgE detected by in house ELISA) | ||||||
| Concentration of asIgE to Dermatophagoidesd | GM: 60.3 | GM: 73.8 | 1.13 (0.36–3.50) | .83 | 1.17 (0.39–3.51) | .78 |
| Concentration of asIgE to German cockroachd | GM: 72.4 | GM: 161.0 | 1.98 (0.59–6.63) | .25 | 1.51 (0.45–5.04) | .49 |
Abbreviations: asIgE, allergen-specific IgE; CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; GM, geometric mean; GMR, geometric mean ratio; IgE, immunoglobulin E; RR, risk ratio; SPT, skin prick test positivity.
aAtopy outcomes assessed by IgE were adjusted for age and sex only.
bFor this outcome, a natural log transformation was applied to village-level proportions to correct skewed distributions, and the data in parentheses are the geometric means of village proportions.
cLog10(+0.001) transformation at the individual level.
dLog10(+1) transformation at the individual level.