Figure 5.

Effect of miR-31 on the Growth of Oral Cancer PDX In Vivo

(A) Representative images of oral cancer PDX model mice. Mice were intratumorally injected with antagomiR-31-5p (n = 6), and antagomiR-NC served as a control (n = 6) in every case. (B) Representative images of tumor tissues from PDX model mice at 28 days after treatment. (C) Tumor growth curves of oral cancer PDX. AntagomiR-31-5p significantly inhibited PDX growth in two patients. **p < 0.01. (D) Relative expression levels of miR-31-5p in PDX tumors were assessed by real-time qPCR after normalizing to U6. The vertical lines represent the 25th percentile value, the mean value, and the 75th percentile value of the observations. *p < 0.05; **p < 0.01.