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. 2014 Aug 28;21(1):32–39. doi: 10.1111/cns.12318

Figure 3.

Figure 3

Frequency‐dependent inhibition of the TRPM7 current by lidocaine in HEK‐293 cells overexpressing TRPM7 channels. (A and B) TRPM7 current was recorded, with an interval of 6 seconds, in the absence or presence of 10 mM lidocaine, respectively. Three stable currents were recorded before the treatment with lidocaine. (C) TRPM7 current was recorded in the presence of 10 mM lidocaine with an interval of 16 seconds. (D) Summary data showing time‐dependent decrease of TRPM7 current in the absence (black circle, stimulating interval of 6 seconds, n = 5) or presence of 10 mM lidocaine (red circle, stimulating interval of 6 seconds, n = 5; green triangle, stimulating interval of 16 seconds, n = 6). (Two‐way ANOVA followed by Bonferroni posttests, *P < 0.5, **P < 0.01). Arrows represent the initial administration of lidocaine. (E and F) Representative current traces and summary data showing the lack of inhibition on TRPM7 current by lidocaine. Lidocaine was applied only when the channel was inactivated (n = 8).