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. 2014 Aug 28;21(1):32–39. doi: 10.1111/cns.12318

Figure 6.

Figure 6

The effect of QX‐314 and procaine on TRPM7 current in cortical neurons. (A) The structure of lidocaine, QX‐314, and procaine. Based on their structure, local anesthetics are classified into two series of compounds including amino amide and amino ester. (B) and (C) The representative traces and summary data showing the effect of 10 mM QX‐314 on TRPM7 current in cortical neurons (n = 7, ***P < 0.001). (D) and (E) The representative traces and summary data showing the effect of 10 mM procaine on TRPM7 current in cortical neurons (n = 6, ***P < 0.001). MK‐801 (10 μM) and TTX (0.3 μM) were included in the extracellular solutions to block potential activation of NMDA and voltage‐gated Na+ currents.