Table 3.

Changes in y-intercept and slope of running speed versus theta frequency relationship during optogenetic silencing

	Group	Mean ± SD			n	Df	t Statistic	p	Effect size, Cohen's d
		Baseline	Laser stimulation	Difference
Y-intercept, Hz
Average across mice	Laser control	7.63 ± 0.25	7.58 ± 0.27	−0.06 ± 0.09	6	5	−1.597	0.171	−0.652
	GFP control	7.68 ± 0.58	7.79 ± 0.62	0.11 ± 0.09	5	4	2.873	0.045	1.285
	ChAT-Cre	7.67 ± 0.45	7.78 ± 0.44	0.11 ± 0.09	10	9	3.913	0.004	1.237
Average across sessions	Wild-type, ArchT (n = 4 mice)	8.03 ± 0.67	8.17 ± 0.67	0.14 ± 0.19	38	37	4.409	0.000	0.715
	PV-Cre (n = 3 mice)	8.36 ± 0.94	8.50 ± 0.89	0.14 ± 0.10	12	11	4.946	0.000	1.428
	vGluT2-Cre (n = 3 mice)	8.39 ± 0.99	8.53 ± 0.91	0.14 ± 0.18	39	38	4.647	0.000	0.744
Slope, Hz/(cm/s)
Average across mice	Laser control	0.0232 ± 0.0067	0.0270 ± 0.0059	0.0038 ± 0.0060	6	5	−1.542	0.184	−0.629
	GFP control	0.0268 ± 0.0079	0.0290 ± 0.0079	0.0022 ± 0.0020	5	4	2.378	0.076	1.064
	ChAT-Cre	0.0239 ± 0.0109	0.0220 ± 0.0111	−0.0019 ± 0.0042	10	9	1.435	0.185	0.454
Average across sessions	Wild-type, ArchT (n = 4 mice)	0.0213 ± 0.0132	0.0118 ± 0.0119	−0.0094 ± 0.0135	38	37	−4.291	0.000	−6.96
	PV-Cre (n = 3 mice)	0.0088 ± 0.0053	0.0115 ± 0.0074	0.0027 ± 0.0053	12	11	1.771	0.104	0.511
	vGluT2-Cre (n = 3 mice)	0.0103 ± 0.0116	0.0137 ± 0.0114	0.0034 ± 0.0125	39	38	1.678	0.102	0.269

Df, Degrees of freedom; n, sample size. Statistics were performed across mice if the number of mice ≥5, otherwise across sessions.