Table 4.

Effects of rhythmic optogenetic silencing on LFPs

Group	n	6 Hz	8 Hz	10 Hz	12 Hz	20 Hz	30 Hz	40 Hz	50 Hz
Laser control	5 sessions, 4 mice
	Mean	0.11	0.04	0.22	0.52	0.06	0.14	−0.01	−0.10
	SD	0.26	0.34	0.68	0.60	0.20	0.21	0.13	0.16
	p value	0.9020	0.3745	0.0399	0.2840	0.9735	0.0159	0.7464	0.9604
	Cohen's d	0.44	0.12	0.33	0.87	0.30	0.68	−0.07	−0.62
GFP control	18 sessions, 5 mice
	Mean	0.16	0.07	0.17	0.21	0.13	0.08	0.03	−0.02
	SD	0.36	0.40	0.55	0.62	0.37	0.33	0.17	0.23
	p value	0.0539	0.1564	0.0412	0.2673	0.0760	0.6703	0.9194	0.9745
	Cohen's d	0.44	0.17	0.30	0.34	0.35	0.25	0.18	−0.11
ChAT-Cre	11–16 sessions, 6–7 mice
	Mean	0.65	0.34	0.53	0.51	0.19	0.10	0.16	0.18
	SD	0.67	0.76	0.68	0.79	0.58	0.53	0.48	0.43
	p value	0.0065	0.0095	0.0055	0.0209	0.0032	0.0142	0.3497	0.0098
	Cohen's d	0.97	0.45	0.77	0.64	0.34	0.19	0.32	0.41
Wild-type, ArchT	7–8 sessions, 4 mice
	Mean	0.74	1.18	1.80	2.18	1.26	0.84	1.08	0.81
	SD	0.67	0.60	0.39	0.12	0.53	0.63	0.52	0.48
	p value	0.008	0.007	0.003	0.010	0.000	0.002	0.000	0.000
	Cohen's d	1.10	1.97	4.58	17.72	2.38	1.35	2.08	1.70
PV-Cre	5 sessions, 5 mice
	Mean	0.14	0.12	0.54	0.87	0.57	0.51	0.60	0.40
	SD	0.20	0.43	0.50	0.43	0.60	0.25	0.42	0.16
	p value	0.0446	0.0576	0.0018	0.0095	0.0139	0.0035	0.0012	0.0082
	Cohen's d	0.69	0.27	1.09	2.01	0.95	2.04	1.42	2.58
vGluT2-Cre	9–13 sessions, 3 mice
	Mean	0.99	0.96	0.87	0.82	1.19	1.38	0.45	0.12
	SD	0.77	0.74	0.65	0.61	0.44	0.65	0.74	0.36
	p value	0.0062	0.0000	0.0062	0.0082	0.0000	0.0000	0.0038	0.0072
	Cohen's d	1.29	1.29	1.34	1.34	2.67	2.13	0.61	0.34

Statistics on z-scores of spectral power estimates (see Materials and Methods).