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. 2015 Jun 20;21(8):642–650. doi: 10.1111/cns.12416

Figure 1.

Figure 1

IL‐1RA treatment and IL‐1R1‐KO mice enhanced the postictal suppression induced by intermittent MES in mice. (A) The seizure score induced by MES (15 mA) did not changed 15, 30, and 60 min after the injection of IL‐1RA. (B) IL‐1RA enhanced the postictal suppression induced by intermittent MES (n = 7 for each group). (C) IL‐1R1 knockout enhanced the postictal suppression induced by intermittent MES, while IL‐1R1 knockout did not affect the baseline threshold of MES (showed in the histogram inset, n = 10 for each group). The IL‐1R1 knockout mice were identified by PCR analysis. (D) The percentage distribution of mice at different seizure scores in each group induced by the sixth (last) MES test. One‐way ANOVA with LSD post hoc was used in panel A; two‐way ANOVA for repeated measures and paired t‐test for paired data were used in panels B and C; Student's t‐test was used for comparing the threshold of MES in panel C. *P < 0.05 and **P < 0.01 represent differences from the control or WT group, respectively. # P < 0.05, ## P < 0.01, and ### P < 0.001 represent differences from the first MES test, respectively.