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. 2015 Jun 20;21(8):642–650. doi: 10.1111/cns.12416

Figure 4.

Figure 4

IL‐1R1‐KO mice impaired the kindling acquisition and expression. Effects of IL‐1R1‐KO on behavioral stage of seizures (A) and afterdischarge duration (ADD) (B) during hippocampal kindling acquisition (n = 10 for WT and n = 8 for IL‐1R1‐KO groups). The inset of (A) shows the prekindling afterdischarge threshold (ADT) of each group. (C) Effect of IL‐1R1 knockout on the number of stimulations required to reach each seizure stage. (D) The mean postkindling ADT determined by stimulations with an interstimulation interval of 1 or 5 min (n = 5 for WT and n = 6 for IL‐1R1‐KO groups, the WT mice were just fully kindled and used here to avoid the influence of repeated stage 5 seizures). (E) The incidence of ADT that can be determined by stimulations with an interstimulation interval of 1 or 5 min. (F) The incidence of generalized seizures induced by repeated kindling stimulation (at 400 μA) with a 30‐min interval (n = 5 for WT and n = 6 for IL‐1R1‐KO groups). Two‐way analysis of variance (ANOVA) for repeated measures was used for A and B; Student's t‐test for paired data was also used for comparing the thresholds between the IL‐1R1‐KO and WT mice in A and D; the chi‐square test was used for E and F. *P < 0.05 represents differences from the WT group.