Fig. 6.

Schematic diagram of the eicosanoid metabolites regulated by AMPK activation to reverse the effects of HFD in the kidney, urine, and arterial and venous circulation. Adrenic acid metabolites, dihomo-PGF_2α and dihomo-15d-PGD₂; AA metabolites, PGEM and PGFM, and PGF_2α; EPA metabolites, PGE₃, TXB₃, and 5-HEPE; ALA metabolite, 9-HOTrE; DHA metabolites, 19,20-DiHDPA, 16-HDoHE, 15(t)-PD₁, 7-HDoHE, 11-HDoHE, 8-HDoHE, and 13-HDoHE; and finally LA metabolites, 9,10-diHOME; 12,13-EpOME, and 12,13-diHOME. Red font indicates that HFD increases these metabolites and AICAR reverses them, while blue font indicates the metabolite is decreased with HFD and AICAR reverses this trend.