TABLE 3.

Eicosanoid metabolites altered with HFD in the arterial circulation

Name	Acronym	MECH	STD	HFD	P	q Value
Up with HFD
AA metabolites
Arachidonic acid	AA	PUFA	8,771.3 ± 1,930.9	14,906.2 ± 2,726.5	0.002	0.011
8,9-Epoxy-eicosatrienoic acid	8,9-EET	P450	0.10 ± 0.14	3.77 ± 3.41	0.001	0.005
Down with HFD
ALA metabolites
9-Hydroxy-octatrienoic acid	9-HOTrE	LOX	2.97 ± 0.90	0.99 ± 0.31	<0.001	0.003
DHA metabolites
4-Hydoxy-docosahexaenoic acid	4-HDoHE	LOX	8.93 ± 1.43	3.45 ± 0.91	<0.001	0.001
11-Hydoxy-docosahexaenoic acid	11-HDoHE	LOX	3.03 ± 1.13	1.35 ± 0.80	0.014	0.042
16-Hydoxy-docosahexaenoic acid	16-HDoHE	P450	1.49 ± 0.55	0.58 ± 0.17	0.002	0.012
10-Hydoxy-docosahexaenoic acid	10-HDoHE	NE	2.56 ± 0.92	1.05 ± 0.52	0.009	0.031
13-Hydoxy-docosahexaenoic acid	13-HDoHE	NE	3.62 ± 0.27	1.94 ± 0.81	0.010	0.035
20-Hydoxy-docosahexaenoic acid	20-HDoHE	NE	1.49 ± 0.62	0.11 ± 0.10	0.002	0.012
EPA metabolites
EPA	EPA	PUFA	12,331.9 ± 4,377.1	4,870.6 ± 1,329.8	0.003	0.016
5-Hydroxy-eicosapentaenoic acid	5-HEPE	LOX	2.53 ± 0.28	0.38 ± 0.13	<0.001	0.000
12-Hydroxy-eicosapentaenoic acid	12-HEPE	LOX	33.76 ± 22.64	4.46 ± 3.22	0.004	0.018
15-Hydroxy-eicosapentaenoic acid	15-HEPE	LOX	1.65 ± 0.45	0.20 ± 0.13	0.004	0.018
14(15)-Epoxy-eicosatetraenoic acid	14,15-EpETE	P450	0.56 ± 0.18	0.18 ± 0.05	<0.001	0.004
9-Hydroxy-eicosapentaenoic acid	9-HEPE	NE	3.56 ± 1.84	0.11 ± 0.13	<0.001	0.003
11-Hydroxy-eicosapentaenoic acid	11-HEPE	NE	1.45 ± 0.18	0.18 ± 0.07	<0.001	<0.001
18-Hydroxy-eicosapentaenoic acid	18-HEPE	NE	1.51 ± 0.26	0.19 ± 0.11	<0.001	<0.001
LA metabolites
9,10-Dihydroxy-octadecanoic acid	9,10-diHOME	P450	16.71 ± 6.03	7.38 ± 4.10	0.013	0.042
12,13-Epoxy-octadecanoic acid	12,13-EpOME	P450	12.65 ± 3.65	5.52 ± 2.11	0.002	0.012
12,13-Dihydroxy-octadecanoic acid	12,13-diHOME	P450	38.64 ± 13.16	10.86 ± 6.82	0.001	0.008
13-Hydroxy-octadecadienoic acid	13-HODE	NE	61.13 ± 20.15	23.91 ± 8.93	0.005	0.018

All values are picomoles per milliliter of plasma expressed as mean ± SD. MECH, mechanism.