TABLE 6.

The trends in the arterial and venous blood of highly correlated metabolites using PC analysis

Variable	PC Variables	PC Variance	ANOVA P	Post Hoc P
			All	STD versus HFD	HFD versus HFD+AICAR
Artery
AA
LOX	9	40.9	0.73	1	1
13 PGR	2	70.3	0.42	0.60	1
COX	6	59.9	0.90	1	1
P450	13	49.3	0.13	0.43	0.16
EPA
LOX	3	78.9	0.000003	0.00004a	0.72
DHA
LOX	2	79.9	0.001	0.003a	1
P450	2	78.1	0.01	0.03a	1
NE	4	77.1	0.01	0.01a	1
LA
NE	2	92.8	0.32	0.43	0.97
ALA
LOX	3	75.7	0.04	0.03a	0.37
Vein
AA
LOX	8	59.4	0.87	1	1
13 PGR	2	50.5	0.06	0.06	0.47
COX	5	67.2	0.84	1	1
P450	15	47.9	0.12	1	0.19
EPA
LOX	3	78.0	0.00002	0.00003a	0.60
NE	2	82.4	0.00004	0.0003a	1
DHA
LOX	3	58.0	0.0004	0.002a	1
NE	3	73.9	0.08	0.09	0.76
LA
NE	2	90.4	0.11	0.79	0.11
ALA
LOX	3	73.7	0.02	0.03a	0.09

PC variables, number of eicosanoids in the PC; PC variance, amount of variance explained by the PC; ANOVA P, P generated comparing all three groups; HFD+AICAR, high-fat diet and AICAR therapy; 13 PGR, delta13-15-ketoprostaglandin reductase; PGDH, 15-hydroxyprostaglandin dehydrogenase.

^aDecreased with HFD.