TABLE 4.

Interaction between ELOVL2/5 haplotype and DHA intake on breast-milk PUFA level

	LA		GLA		DGLA		ARA		DTA		ALA		EPA		DHA
	coef	P	coef	P	coef	P	coef	P	coef	P	coef	P	coef	P	coef	P
ELOVL2
Q1a	Reference
Q2a	−0.0243	0.644	−0.0161	0.344	−0.0047	0.567	−0.0053	0.635	−0.0012	0.654	−0.0099	0.643	−0.0084	0.333	−0.0031	0.876
H1b	Reference
H2b	−0.0723	0.046	−0.0205	0.093	−0.0065	0.253	−0.0125	0.107	−0.0022	0.251	−0.0253	0.083	−0.0143	0.022	−0.0364	0.008
Q1-H1c	Reference
Q2-H2c	0.1107	0.038	0.0329	0.060	0.0108	0.192	0.0255	0.025	0.0040	0.143	0.0385	0.072	0.0190	0.034	0.0586	0.004
ELOVL5
Q1a	Reference
Q2a	−0.0144	0.790	−0.0144	0.406	−0.0023	0.780	0.0005	0.967	−0.0004	0.891	−0.0327	0.128	−0.0102	0.246	−0.0193	0.342
Q4a	−0.0450	0.374	−0.0126	0.437	−0.0072	0.345	−0.0136	0.204	−0.0024	0.351	−0.0223	0.267	−0.0020	0.812	0.0036	0.851
H1b	Reference
H4b	−0.0546	0.376	−0.0280	0.157	−0.0098	0.295	−0.0145	0.264	−0.0040	0.205	−0.0131	0.595	−0.0168	0.095	−0.0329	0.157
H5b	−0.0086	0.886	0.0081	0.672	0.0031	0.736	−0.0043	0.735	−0.0011	0.721	−0.0034	0.886	−0.0106	0.273	−0.0172	0.473
Q1-H1c	Reference
Q2-H4c	0.0341	0.699	0.0213	0.455	0.0030	0.829	0.0093	0.615	0.0003	0.953	0.0679	0.053	0.0072	0.611	0.0434	0.185
Q4-H4c	0.1994	0.068	0.0603	0.084	0.0385	0.020	0.0326	0.159	0.0046	0.409	0.0998	0.022	0.0359	0.042	0.0621	0.129
Q2-H5c	0.1158	0.238	0.0250	0.452	0.0318	0.036	0.0382	0.069	0.0083	0.099	0.0527	0.182	0.0424	0.011	0.0550	0.141
Q4-H5c	−0.0068	0.944	0.0446	0.162	0.0059	0.694	0.0029	0.887	0.0020	0.695	−0.0055	0.885	0.0393	0.015	0.0600	0.124

^aQuartile level of DHA intake. Q₁: < 14.58 mg/day (reference); Q₂: 14.58–43.15 mg/day; and Q₄: ≥118.82 mg/day.

^bType of haplotype. ELOVL2, H₁: A-C-C (reference); ELOVL2, H₂: A-G-G; ELOVL5, H₁: C-A-C-G-A (reference); ELOVL5, H₄: A-A-C-A-A; and ELOVL5, H₅: C-A-C-A-A. Haplotypes are named according to their frequency.

^cEffect of interaction between DHA intake and haplotype on PUFA levels compared with the reference.