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Model for the role of the AdipoRs in membrane homeostasis. In healthy cells challenged with exogenous SFAs, the AdipoRs sense membrane rigidification and signals to promote desaturase enzyme expression, resulting in increased incorporation of fluidizing UFAs into phospholipids. AdipoR-deficient cells fail to promote desaturase activity to compensate for the exogenously provided SFAs that become incorporated into phospholipids, leading to membrane rigidification and hence lipotoxicity.
