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. 2019 Feb 22;60(5):972–980. doi: 10.1194/jlr.M091066

Fig. 1.

Fig. 1.

LPAR4 deficiency in male mice reduces atherosclerosis but has no effect on plasma cholesterol profiles. A: Total cholesterol in plasma from individual WT (dark circles) or Lpar4Y/− (open circles) mice infected with PCSK9D377Y.AAV and fed a Western diet for 20 weeks (P = 0.94). B: Plasma lipoprotein particles were resolved by size-exclusion chromatography and total cholesterol in the indicated fractions (n = 3 mice/genotype determined). C: Images of representative aortas from WT and Lpar4Y/− mice. D: En face analysis of atherosclerotic lesions from the ascending aorta to 3 mm below the subclavian artery. The atherosclerotic lesion area/total aortic area for individual WT (dark circles) or Lpar4Y/− (open circles) mice is presented (P = 0.009). E: Atherosclerosis lesion area plotted as a function of plasma cholesterol in WT (dark circles) or Lpar4Y/− (open circles) mice.