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. 2014 Jun 13;47(4):299–309. doi: 10.1111/cpr.12115

Figure 6.

Figure 6

Possible pathway of hUC ‐MSC differentiation towards male germ‐like cells under induction of BMP4. In the presence of BMP4, SSEA‐1+ cells in hUC‐MSCs upregulated PGC‐associated transcriptional factors, PRDM1, PRDM14, STELLA, SSEA‐1, C‐KIT and SOX2. Meanwhile, these cells shrank in size, became round‐shaped in morphology, increased nucleus‐cytoplasmic ratio. Thereafter, male germ‐cell markers, STRA8, SCP3, DMRT1 and PLZF, greatly increase. Finally, these cells were induced to differentiate towards male germ cells.