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. 2019 May;60(5):617–622. doi: 10.2967/jnumed.118.218792

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FIGURE 2. — Dynamics of ⁸⁹Zr-BVDFO delivery with and without BBB opening. (A–C) Representative axial, sagittal, and coronal PET/CT images showing brain uptake with IA/BBBI (A), BBBO/IA (B), and IV/BBBO (C). (D) Graph showing faster and higher ipsilateral hemisphere uptake with BBBO/IA (red) than with IA/BBBI (blue) or IV/BBBO (gray). (E) Graph showing increase in heart uptake with IA/BBBI (blue), BBBO/IA (red), and IV/BBBO (gray) (n = 4). No increase in brain uptake was observed with IV/BBBO on 45-min dynamic PET scans. NS = statistically nonsignificant. *Statistically significant difference.