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. 2015 May 21;21(7):585–590. doi: 10.1111/cns.12406

Figure 2.

Figure 2

Effects of PDC (FeTMPyP, 3 mg/kg) on neurological severity scores (NSS) in MCAO ischemic rats with early and delayed t‐PA treatments. Rats were treated with t‐PA (10 mg/kg) at 2 and 5 h of MCAO ischemia following 22 and 19 h of reperfusion, respectively. M2/R22, 2 h of MCAO plus 22 h of reperfusion; M5/R19, 5 h of MCAO plus 19 h of reperfusion. A: t‐PA treatment at 2 h after MCAO ischemia with or without PDC cotreatment (***P < 0.001, VS. sham control; ## P < 0.01, compared to M2/R22). B: t‐PA treatment at 5 h after MCAO ischemia with or without PDC cotreatment (***P < 0.001, compared to sham control; ## P < 0.01, compared to M5/R19; &&& P < 0.001, compared to M5/R19 +  t‐PA). Data are expressed as mean ± SEM (n = 6–11).