Table 1.

Effect of spleen removal on brain infarct

	Stroke model	Infarct	Time of spleen removal	Species	Duration of occlusion	Time of observation	Citations
1	MCAO	↓	2 weeks before MCAO	Rat	Permanent	96 h	13
2	MCAO	↓	2 weeks before MCAO	Rat	Permanent	24 h	45
3	MCAO	↓	2 weeks before MCAO	Rat	Permanent	96 h	12
4	MCAO	↓	2 weeks before MCAO	Rat	Permanent	48 h	4
5	MCAO	↓	2 weeks before MCAO	Rat	Permanent	96 h	40
6	MCAO	↓	Splenic irradiation 3, 4, 6, or 8 h after start of cerebral ischemia	Rat	2 h	2 and 7 days	35
7	MCAO	↓	2 weeks before MCAO	Mouse	60 min	5 days	66
8	MCAO	—	Immediately before MCAO	Mouse	30 min	3 and 7 days	36
9	Hypoxia–ischemia (HI)	↓	3 days before HI	Neonatal rat	Permanent followed by 2 h of hypoxia	72 h	67

MCAO, middle cerebral artery occlusion.