FIG 1.

Disruption of subtelomeric silencing dramatically enhances fungal adhesion to abiotic surfaces. (A) AFM-based single-cell force spectroscopy was used to measure the forces between single WT C. glabrata cells and hydrophilic (hydroxyl-terminated) or hydrophobic (methyl-terminated) substrates. Shown here are the adhesion force and rupture length histograms with representative retraction force profiles for three different WT cells interacting with hydrophilic (left) and hydrophobic (right) substrates. (B, C) Force data obtained for the interaction of the ura3Δ sir3Δ (B) and ura3Δ (C) mutant strains. For results on more cells, see Fig. S1 in the supplemental material.