Table 3. Case-Only Analyses of the Associations of PRS-MD, PRS-BD, and PRS-SZ With Age at Onset and Severity at First Depression Diagnosis.
| Characteristic | MD | BD | SZ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| β (SE) | OR (95% CI) | P Value | β (SE) | OR (95% CI) | P Value | β (SE) | OR (95% CI) | P Value | |
| Age at depression diagnosis | −0.05 (0.02) | NA | .04 | −0.07 (0.02) | NA | .002 | −0.05 (0.02) | NA | .04 |
| ICD-10 severity specifier | |||||||||
| Mild | Reference Category | ||||||||
| Moderate | −0.00 (0.02) | 1.00 (0.95-1.05) | .99 | −0.03 (0.02) | 0.97 (0.93-1.02) | .24 | 0.04 (0.02) | 1.04 (0.99-1.09) | .08 |
| Severe | −0.05 (0.03) | 0.95 (0.89-1.01) | .13 | 0.02 (0.03) | 1.02 (0.95-1.08) | .62 | 0.02 (0.03) | 1.02 (0.95-1.09) | .58 |
| Psychotic | 0.02 (0.05) | 1.02 (0.92-1.12) | .71 | 0.06 (0.05) | 1.06 (0.97-1.17) | .21 | 0.09 (0.05) | 1.10 (1.00-1.21) | .06 |
| Unspecified | −0.01 (0.03) | 0.99 (0.94-1.04) | .77 | −0.02 (0.03) | 0.98 (0.93-1.03) | .48 | 0.02 (0.03) | 1.02 (0.97-1.07) | .51 |
| Treatment setting | |||||||||
| Outpatient | Reference Category | ||||||||
| Emergency | 0.05 (0.02) | 1.05 (1.01-1.09) | .02 | 0.03 (0.02) | 1.03 (0.99-1.07) | .18 | 0.03 (0.02) | 1.03 (0.99-1.07) | .13 |
| Inpatient | 0.04 (0.02) | 1.04 (0.99-1.09) | .13 | 0.02 (0.02) | 1.02 (0.98-1.07) | .37 | 0.02 (0.02) | 1.02 (0.97-1.07) | .46 |
Abbreviations: BD, bipolar disorder; ICD-10, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision; MD, major depression; NA, not applicable; OR, odds ratio; PRS, polygenic risk score; SZ, schizophrenia.