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. 2019 Apr 30;10(2):e00693-19. doi: 10.1128/mBio.00693-19

FIG 2.

FIG 2

Combo5 antigen-specific IgG response in NHP serum. Serum samples from Combo5-immunized (n = 5) (blue lines) and PBS-immunized (n = 5) (black lines) NHPs were collected before each immunization on weeks 0, 8, and 17; prior to infection on week 20; and postinfection on week 20 (days 1, 2, and 3 postinfection), week 21 (day 7 postinfection), week 22 (day 14 postinfection), week 23 (day 21 postinfection), week 24 (day 28 postinfection), and week 25 (1 week after antibiotic treatment). Antibody titers at the time of infection (week 20) were significantly higher for all antigens in Combo5-immunized NHPs than in PBS-immunized NHPs (P < 0.0001). Infection and antibiotic treatment days are marked by red and green arrows, respectively. Duration of GAS infection is indicated by the gray-shaded area. IgG responses against ADI (A), SCPA (B), SLO (C), SpyCEP (D), and TF (E) were induced in Combo5-immunized NHPs following immunization. Infection with GAS M1T1 5448 significantly raised IgG titers against SCPA (B), SLO (C), and SpyCEP (D) antigens in PBS-immunized NHPs. Values represent the geometric mean (geomean) titers ± geometric SD.