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. 2015 Feb 10;21(6):504–512. doi: 10.1111/cns.12384

Figure 2.

Figure 2

The inhibition of TREK‐1 channel currents by escitalopram. (A) The record of typical TREK‐1 background potassium currents by the whole‐cell patch‐clamp technique in HEK293 cells transfected with the TREK‐1‐pEGFP‐N1 plasmid. (B) The significant inhibition of the TREK‐1 current by escitalopram (at 0 mV with 10, 30, 50, 100, and 500 μM) as compared with the vehicle (n = 6 each, all *P < 0.05). (C) The concentration response curve for the escitalopram‐mediated inhibition of the TREK‐1 current. The IC50 value at 0 mV is 81.94 μM. (D) There is no significant change in the percentage inhibition of the TREK‐1 current within the voltage range from −40 to +40 mV. All of the data are represented as the mean ± SD.