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Photomicrographs of Luxol fast blue staining of the white matter. Nerve fibers were neat in sham‐operated rats (A, B, C). Marked leukoaraiosis was observed in vehicle‐treated RHRSP (D, E, F). Pioglitazone‐treated RHRSP showed significantly less WML (G, H, I). RHRSP, stroke‐prone renovascular hypertensive rats; WML, white matter lesion; RHRSP/veh, RHRSP treated with vehicle; RHRSP/pio, RHRSP treated with pioglitazone.
