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. 2019 Apr 16;10:360. doi: 10.3389/fphar.2019.00360

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Copyright © 2019 Ruaro, Smith, Sulli, Pizzorni, Tardito, Patané, Paolino and Cutolo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Laser Speckle Contrast Analysis (LASCA) images of secondary Raynaud’s phenomenon (RP) to systemic sclerosis, in a patient with a “Late” pattern of scleroderma microangiopathy (A), primary RP (B) and a healthy subject (C), showing the regions of interest (ROI - white circles) created at the level of dorsum and palm of the hand, dorsal and palmar aspect of the 3rd finger, periungual areas and fingertips to evaluate blood perfusion. Color code: blue corresponds to a low BP, yellow an intermediate BP and red a higher BP. Noteworthy is the fact that subjects with a late pattern have a prevalence of blue, indicating a low perfusion level.