Table 2.
Blood perfusion (BP) in systemic sclerosis (SSc), primary Raynaud’s phenomenon (PRP) and healthy subjects (CNT).
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | Statistical significance |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CNT # 70 | PRP # 31 | SSc # 68 | Early # 22 | Active # 23 | Late # 22 | CNT vs. PRP | CNT vs. SSc | PRP vs. SSc | E vs. A | E vs. L | A vs L | |
| BP fingertips | 187 (72) | 90 (28) | 88 (25) | 92 (58) | 88 (19) | 82 (40) | p < 0.0001 | p < 0.0001 | p = 0.6 | p = 0.2 | p = 0.006 | p = 0.1 |
| BP palmar aspect of the 3rd phalanx | 134 (74) | 84 (19) | 81 (27) | 88 (25) | 80 (20) | 72 (35) | p < 0.0001 | p < 0.0001 | p = 0.4 | p = 0.06 | p = 0.007 | p = 0.2 |
| BP palm of hands | 114 (27) | 81 (22) | 79 (31) | 85 (22) | 83 (31) | 68 (39) | p < 0.0001 | p < 0.0001 | p = 0.05 | p = 0.4 | p = 0.01 | p = 0.04 |
| BP periungual areas | 143 (51) | 78 (28) | 76 (38) | 82 (34) | 76 (47) | 68 (42) | p < 0.0001 | p < 0.0001 | p = 0.7 | p = 0.1 | p = 0.02 | p = 0.3 |
| BP dorsal aspect of the 3rd phalanx | 55 (28) | 59 (16) | 58 (24) | 61 (19) | 59 (25) | 57 (24) | p = 0.5 | p = 0.09 | p = 0.8 | p = 0.2 | p = 0.3 | p = 0.6 |
| BP dorsum of hands | 51 (27) | 50 (13) | 52 (18) | 56 (22) | 50 (19) | 49 (16) | p = 0.4 | p = 0.07 | p = 0.9 | p = 0.1 | p = 0.1 | p = 0.8 |
| BP forehead | 109 (44) | 113 (32) | 110 (33) | 112 (21) | 110 (29) | 111 (31) | p = 0.1 | p = 0.09 | p = 0.3 | p = 0.2 | p = 0.3 | p = 0.8 |
| BP tip of nose | 129 (45) | 139 (42) | 130 (42) | 132 (42) | 129 (36) | 130 (56) | p = 0.2 | p = 0.09 | p = 0.3 | p = 0.5 | p = 0.09 | p = 0.3 |
| BP zygoma | 127 (48) | 155 (45) | 145 (58) | 150 (45) | 145 (55) | 143 (83) | p = 0.4 | p = 0.1 | p = 0.2 | p = 0.3 | p = 0.2 | p = 0.1 |
| BP perioral region | 144 (48) | 141 (39) | 135 (46) | 134 (45) | 136 (46) | 134 (56) | p = 0.1 | p = 0.1 | p = 0.3 | p = 0.2 | p = 0.1 | p = 0.3 |
| BP whole face | 135 (34) | 146 (28) | 136 (42) | 140 (32) | 131 (36) | 130 (68) | p = 0.2 | p = 0.3 | p = 0.1 | p = 0.2 | p = 0.1 | p = 0.2 |
SSc patients with different capillaroscopic patterns of nailfold microangiopathy (Early, Active, Late), evaluated by LASCA in different areas of the hands (fingertips, periungual areas, dorsal and palmar aspect of the 3rd phalanx bilaterally, dorsum and palms of both hands) and face (forehead, tip of nose, zygomas and perioral region). Statistical significance: Mann-Witney U-test (# = numbers, E = Early, A = Active, L = Late). The statistical significance columns show the blood perfusion difference between the CNT (healthy subjects) and the PRP (primary Raynaud’s phenomenon) and the systemic sclerosis (SSc) patients. The three capillaroscopic patterns of nailfold microangiopathy (Early, Active, Late), evaluated by LASCA, are also documented.