Table 1.
Functional characterization of the deregulated miRNAs in chordoma
| Name | Up‐ or down‐regulation | Target gene | Role | Reference |
|---|---|---|---|---|
| miR‐1 | Down | Met, HDAC4, Slug | Tumour suppressor | 44, 45, 46 |
| miR‐206 | Down | Tumour suppressor | 44 | |
| miR‐1237‐3p | Down | Tumour suppressor | 47 | |
| miR‐140‐3p | Up | Oncogene | 7 | |
| miR‐148a | Up | Oncogene | 48 | |
| miR‐31 | Down | c‐MET, radixin | Tumour suppressor | 48 |
| miR‐222 | Down | Tumour suppressor | 48 | |
| miR‐10a | Down | Tumour suppressor | 49 | |
| miR‐125a | Down | Tumour suppressor | 49 | |
| MiR‐140‐3p | Up | Oncogene | 50 | |
| MiR‐608 | Down | EGFR, Bcl‐xL | Tumour suppressor | 50 |
| miR‐34a | Down | MET | Tumour suppressor | 50 |