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Involvement of MEKand NFκB pathways and PGE2 production on cellular response to E. arvense extract. TRAP activity of PBMC cultures maintained in base medium (BM) or supplemented with M‐CSF and RANKL (M+R) and co‐cultures of PBMC + hBMC cells, maintained in absence (control) or presence of 0.004 mg/ml Equisetum arvense extract. Cell cultures were treated with 1 or 10 μm U0126, 10 or 100 μm PDTC and 1 μm indomethacin. *Significantly different from control cultures.
