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Schematic illustration of the coordination between puerarin and NGF to regulate neuritogenesis. NGF induces Signal‐1 to prime the cells to the ready‐to‐go differentiation state, whereas puerarin effectively promotes the activation of protein kinases ERK1/2 and Akt, leading to nuclear translocation of Nrf2 as Signal‐2. Ultimately, the cross talks between Signal‐1 and Signal‐2 drive the neurite outgrowth.
