Table 3.
Abuse-Related Events Reported For Quetiapine, Olanzapine, Aripiprazole, and Risperidone.
| Reported eventa | Quetiapine events, n (%) | Olanzapine events, n (%) | Aripiprazole events, n (%) | Risperidone events, n (%) |
|---|---|---|---|---|
| Drug abuse | 895 (29) | 324 (21) | 147 (11) | 133 (11) |
| Overdose | 823 (26) | 626 (40) | 346 (25) | 377 (32) |
| Intentional overdose | 545 (17) | 331 (21) | 454 (33) | 320 (27) |
| Intentional product misuse | 544 (17) | 140 (9) | 118 (8) | 155 (13) |
| Drug withdrawal syndrome | 274 (9) | 112 (7) | 162 (12) | 100 (9) |
| Intentional product use issue | 146 (5) | 37 (2) | 66 (5) | 42 (4) |
| Drug dependence | 127 (4) | 37 (2) | 47 (3) | 46 (4) |
| Euphoric mood | 52 (2) | 33 (2) | 43 (3) | 25 (2) |
| Substance abuse | 35 (1) | 6 (0.4) | 38 (3) | 29 (3) |
| Dependence | 19 (0.6) | 10 (0.6) | 28 (2.0) | 19 (1.6) |
| Drug diversion | 18 (0.6) | 5 (0.3) | 4 (0.3) | 22 (1.9) |
| Drug abuser | 2 (0.1) | 2 (0.1) | 5 (0.4) | 3 (0.3) |
| Total global events reported to FAERS | 27 962 | 19 228 | 29 699 | 45 518 |
| Total abuse-related events (% of total events) | 3144 (11%) | 1548 (8%) | 1380 (5%) | 1168 (3%) |
| Total non-overdose abuse-related events | 1926 | 675 | 630 | 532 |
| Deaths among abuse-related events | 673 | 200 | 88 | 143 |
| Deaths among non-overdose abuse-related events | 396 | 90 | 17 | 41 |
| Deaths among overdose abuse-related events | 277 | 110 | 71 | 102 |
a
Multiple reactions might be listed for a specific case.