Figure 6.

Results of inhibitor study. A, The mRNA levels of Efnb2 and Ephb4 both showed no difference between 6 kPa group and 109 kPa group different after treatment with farnesylthiosalicylic acid; B, C, Western blot analyses also showed that the regulatory role of matrix stiffness was blocked after treatment with farnesylthiosalicylic acid. Data shown are representative of three independent experiments; D, Schematic diagram illustrating the mechanism by which the arteriovenous differentiation of EPCs during vasculogenesis is regulated in response to matrix stiffness