Table 1:

Major clinical and pathological features of the alpha-synucleinopathies

Neurological disorder	Major clinical manifestations	Pathology
Parkinson’s disease	Bradykinesia, muscle rigidity, rest tremor, postural instability	Alpha-synuclein-containing intracytoplasmic Lewy bodies in neurons and Lewy neurites
Dementia with Lewy bodies	Dementia, fluctuating clinical status, hallucinations, parkinsonism	Alpha-synuclein-containing intracytoplasmic Lewy bodies in neurons and Lewy neurites
Multiple system atrophy	Autonomic dysfunction, parkinsonism, cerebellar signs in some	Alpha-synuclein containing glial cytoplasmic inclusions
Pure autonomic failure	Autonomic dysfunction	Alpha-synuclein-containing intracytoplasmic Lewy bodies in neurons and Lewy neurites