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. 2015 Jan 21;48(2):249–258. doi: 10.1111/cpr.12161

Figure 2.

Figure 2

Effect of DVL1 on drug resistance‐related proteins. Western blotting for the drug resistance‐related proteins P‐gp, BCRP and Bcl‐2 in (a) A2780 and A2780/Taxol cells, (b) A2780 cells transfected with pcDNA3.1‐DVL1 or pcDNA3.1 for 72 h, (c) A2780/Taxol cells treated with or without 100 μM compound 3289‐8625 for 72 h, and (d) A2780/Taxol cells transfected with siControl, siDVL1 or siDVL1 plus pcDNA3.1‐DVL1 for 72 h. GAPDH was used as the internal control. The left panels show representative Western blots, and the right panels show relative quantitation of the blots after normalization to GAPDH. In B and D, DVL1 blots were included to confirm either the overexpression of DVL1 from pcDNA3.1‐DVL1 or the silencing of DVL1 by siDVL1. Each experiment was performed in triplicate. Δ P > 0.05; *P < 0.05.