Table 2.
Electrophysiological properties of neurons recorded at days 13–16 and days 20–24
| Days 13–16 | Days 20–24 | |||
|---|---|---|---|---|
| Control | Psora‐4 10 nM | Control | Psora‐4 10 nM | |
| Neurons (n) | 16 | 17 | 19 | 18 |
| INa (nA) | −0.441 ± 0.172 | −0.380 ± 0.123 | −0.657 ± 0.206 | −0.898 ± 0.216* |
| IK (nA) | 1.76 ± 0.22 | 1.71 ± 0.28 | 1.81 ± 0.18 | 2.11 ± 0.27 |
| Vrest (mV) | −60.5 ± 2.8 | −67.4 ± 2.1* | −62.3 ± 3.7 | −70.5 ± 5.0* |
| AP peak (mV) | 46.9 ± 8.7 | 54.9 ± 5.6 | 57.7 ± 9.3 | 63.5 ± 7.6 |
| AHP (mV) | −14.7 ± 3.8 | −14.3 ± 2.8 | −11.0 ± 0.8 | −11.6 ± 2.4 |
| Induced AP frequency (Hz) | 35.9 ± 3.9 | 30.4 ± 0.9 | 27.0 ± 3.6 | 25.1 ± 1.7 |
INa was measured as peak inward current, and IK was measured as peak outward current. Action potential (AP) peak and after‐hyperpolarization (AHP) values were measured in the first action potential of the spike train. Induced AP frequency was measured on those neurons that fired induced continuous APs. *P < 0.05.