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. 2015 Jan 29;21(5):425–434. doi: 10.1111/cns.12375

Figure 2.

Figure 2

Facilitation of fear extinction by intra‐amygdala infusions of leptin. (A) Ob‐R immunoreactivity was colocalized primarily with NeuN in mice LA and BLA. PC: perirhinal cortex; ST: striatum; Scale bar: 50 μm. (B) Western blot confirmed the expression of Ob‐R in LA. (C) Histological reconstructions showing placements of intralateral amygdala cannula tips of the animals included in the data analysis. (D) The percentage of freezing during conditioning (4 CS‐footshock trials), trial‐by‐trial extinction training (10 CS‐alone trials), and extinction test (4 CS‐alone trials). Vehicle (white panes), leptin (gray panes), and MK‐801 + leptin (black panes) injections were administered 30 min before extinction training. (E) Averaged percentage of freezing across all extinction training and extinction test trials. *P < 0.05 versus vehicle in the same session, # P < 0.05 versus leptin (3 μg/μL/side) in the same session, n = 7 for each group.